Key points for the treatment of depression associated with menopause:
-There is an increased risk for depression and anxiety during perimenopause and the menopausal transition, possibly due to fluctuating estrogen in the central nervous system.
-Antidepressants are the current first-line management of menopausal depression. Outcomes are modest or poor.
-Hormonal therapy with estrogen may help in treating menopausal depression.
